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Kailas Kumbhar from Nashik. Patients were allocated into four groups according to the computer software generated random numbers. A comparison with cold propofol and propofol with lignocaine. Non-invasive blood pressure systolic, diastolic and mean and heart rate were recorded. The drugs were prepared by a different person than the person injecting the drugs. There was no statistically significant difference in pain at 5, 10, 15, and 20 sec between the placebo group and groups where hydrocortisone was used as pretreatment [ Figure 2 ].

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Effects of concentration and diluent. Effect of prior administration of cold saline on pain during propofol injection: Mon Patient satisfaction with perioperative care is assuming more importance in the recent years. A blinded researcher assessed the patient’s pain level using a four point verbal rating scale.

Pain was graded from 0 to 3 in accordance to scale advocated by McCrirrick and Hunter. Materials and Methods A prospective, randomized, controlled, double blind study was conducted after approval of the local ethics committee.

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You must verify all the details of this member by your own best means or by some third party professional experts before contacting and dealing with this member. Use of intravenous low dose hydrocortisone pretreatment of the vein does not attenuate pain following propofol injection.


The analgesic effect of fentanyl, morphine, meperidine, and lidocaine in the peripheral veins: Pain on injection of propofol: Second Marriage is no more shocking word these days, people are opting for second marriage now just like that.

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There was no statistically significant difference in the incidence of pain between patients who received hydrocortisone and the placebo group. Prevention of pain on injection of propofol: Efficacy of dexamethasone pretreatment for alleviation of propofol injection pain.

Support Center Support Center. However, pain on injection of propofol is a major drawback. Peripheral veins are innervated with polymodal nociceptors which mediate the pain response to the injection of certain anesthetic agents. National Center for Biotechnology InformationU. Table 1 Comparison of demographic data between the groups.

Ondansetron pretreatment to alleviate pain on propofol injection: Since one of the proposed mechanisms for pain on propofol injection is mediated through the inflammatory pathway, it was hypothesized that pretreatment with steroid would attenuate the pain on propofol injection.

Role of hydrocortisone in prevention of pain on propofol injection

Group LG had significantly lower incidence of pain. There was significant difference in pain between group LG and the other three groups yaadav 10, 15, and 20 sec. Patients with history of allergy to propofol, neurological or cardiovascular disease, and patients with nae, difficult airway, pregnant patients, and patients on medication with pain modifying drugs were excluded from the study. The use of steroid as a sole agent may not be sufficient to attenuate this pain of multiple etiology.


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Sivakumar Dhakshinamoorthy from Chennai. Comparison of hemodynamic changes after propofol injection. Effect of diluting propofol on the incidence of pain on injection and venous sequelae.

Group NS – patients receiving 2 ml 0.

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A prospective, randomized, controlled, double blind study was conducted after approval of the local ethics committee. Role of hydrocortisone jonu attenuating pain has not been evaluated.

Author information Copyright and License information Disclaimer. Certain methodological limitations could have contributed to the lower efficacy of hydrocortisone. Statistically significant variables were further subjected to Posthoc analysis by non-parametric method.